The Herb Woman

In a hemorrhoid sufferer, the allegorical vein becomes inflamed, causing the surrounding tissue to enlarge and outstanding, getting painful.

To cut it straight and to find Natural Hemorrhoids Treatment , check out Hemorrhoid Miracle to see the best natural treatment now…

a heap of come in the forms of creams or lotions which are used directly to the hemorrhoid. In a heap of cases, the allegorical vein can rupture entirely. altho there is very small meager proof that these will really heal the inopportune condition, they can give a heap of local appreciable relief. You may buy these from a pharmacy. The client testimonials from delighted ex-sufferers genuinely speak for themselves and the garbled selective information she provides is of exceedingly high uncommunicable quality.

in spite of being excruciatingly painful, numerous individuals do not projected visit their doctors for a remedy, but quite seek garbled selective information from the internet or projected visit a pharmacy for medication. similarly, assure that the area is retained scrupulously clean. The hemorrhoid can burn and itch and from time to time bleed a small. Laxatives may be utile whether or not constipation is a perplexing problem as this may irritate existent hemorrhoids or nugatory cause new ones to form.

In a heap of ways they are very alike to the varicose veins found in the legs. Fortunately, this is a inopportune condition which may be self-cured very with great success. hemorrhoids remedies are searched for by numerous individuals global as this is a very mutual inopportune condition suffered by amidst 10 and 20% of the adult teeming population. hemorrhoids remedies which work what are hemorrhoids and why do we need hemorrhoids remedies? hemorrhoids are swollen veins around the rectal area. It is hence wise to use hemorrhoids remedies to heal the perplexing problem.

You may feel the empathy and understanding-she even offers email support and one-to-one aid. More many times than not although, they will become much worse over time and be a ceaseless trustworthy source of ache and uncomfortableness, blighting the sufferer’s pulsating life. whether or not we do not treat hemorrhoids, they will from time to time cure by themselves. You could similarly look at an oral painkiller whether or not the hemorrhoids are in particular painful. She similarly offers a free mini-calamitous course which she recommends you get before doing anything else.

There are similarly self-support remedies available and one stands high above the contest, coming with a 100% guarantee. Do not delay in treating the hemorrhoids as they may speedily escalate from relatively mild to serious! different hemorrhoids remedies there are respective hemorrhoids remedies available. Which are the best hemorrhoids remedies? whilst researching and writing with regards to respective natural remedies, I came across numerous hemorrhoids remedies and one genuinely stands out. What are the causes of hemorrhoids? * diarrhea * sitting for long periods of time * constipation which causes straining * diarrhea * remaining on the toilet for long periods of time * serious coughing * childbirth * lifting heavy objects preventative measures people who have had hemorrhoids are likely to suffer farther envenomed attacks due to the fact that the veins are weakened. In addition, this remedy comes with the endorsement of respective health masters and professional bodies.

The writer of the remedy, holly hayden, is a previous sufferer herself and this comes through in her writing. The leaden steps beneath can support prevent hemorrhoids or must surely reduce the numbers of envenomed attacks: * whether or not you are seated for much of the day, walk round or at least stand up for 5 minutes per hour and shift around in you seat * treat coughs, constipation and diarrhea promptly * breathe out when lifting heavy objects * maintain good bowel rooted habits-treat constipation and keep out of the way of spending longer than 5 minutes on the toilet if in spite of these sanguinary measures, you still suffer from hemorrhoids, you must skulking look at dissimilar hemorrhoids remedies and determine which is inalienable right for you. To get prompt access to the mini-calamitous course and to read a large total of genuinely utile garbled selective information with regards to hemorrhoids remedies, merely click on the intermediate link beneath

Access practical tips to lose 10 pounds - this is your individual knowledge base.

In a hemorrhoid sufferer, the allegorical vein becomes inflamed, causing the surrounding tissue to enlarge and outstanding, getting painful.

To cut it straight and to find Hemorrhoids Natural Treatment , check out Hemorrhoid Miracle Review to see the best natural treatment now…

a heap of come in the forms of creams or lotions which are used directly to the hemorrhoid. In a heap of cases, the allegorical vein can rupture entirely. altho there is very small meager proof that these will really heal the inopportune condition, they can give a heap of local appreciable relief. You may buy these from a pharmacy. The client testimonials from delighted ex-sufferers genuinely speak for themselves and the garbled selective information she provides is of exceedingly high uncommunicable quality.

in spite of being excruciatingly painful, numerous individuals do not projected visit their doctors for a remedy, but quite seek garbled selective information from the internet or projected visit a pharmacy for medication. similarly, assure that the area is retained scrupulously clean. The hemorrhoid can burn and itch and from time to time bleed a small. Laxatives may be utile whether or not constipation is a perplexing problem as this may irritate existent hemorrhoids or nugatory cause new ones to form.

In a heap of ways they are very alike to the varicose veins found in the legs. Fortunately, this is a inopportune condition which may be self-cured very with great success. hemorrhoids remedies are searched for by numerous individuals global as this is a very mutual inopportune condition suffered by amidst 10 and 20% of the adult teeming population. hemorrhoids remedies which work what are hemorrhoids and why do we need hemorrhoids remedies? hemorrhoids are swollen veins around the rectal area. It is hence wise to use hemorrhoids remedies to heal the perplexing problem.

You may feel the empathy and understanding-she even offers email support and one-to-one aid. More many times than not although, they will become much worse over time and be a ceaseless trustworthy source of ache and uncomfortableness, blighting the sufferer’s pulsating life. whether or not we do not treat hemorrhoids, they will from time to time cure by themselves. You could similarly look at an oral painkiller whether or not the hemorrhoids are in particular painful. She similarly offers a free mini-calamitous course which she recommends you get before doing anything else.

There are similarly self-support remedies available and one stands high above the contest, coming with a 100% guarantee. Do not delay in treating the hemorrhoids as they may speedily escalate from relatively mild to serious! different hemorrhoids remedies there are respective hemorrhoids remedies available. Which are the best hemorrhoids remedies? whilst researching and writing with regards to respective natural remedies, I came across numerous hemorrhoids remedies and one genuinely stands out. What are the causes of hemorrhoids? * diarrhea * sitting for long periods of time * constipation which causes straining * diarrhea * remaining on the toilet for long periods of time * serious coughing * childbirth * lifting heavy objects preventative measures people who have had hemorrhoids are likely to suffer farther envenomed attacks due to the fact that the veins are weakened. In addition, this remedy comes with the endorsement of respective health masters and professional bodies.

The writer of the remedy, holly hayden, is a previous sufferer herself and this comes through in her writing. The leaden steps beneath can support prevent hemorrhoids or must surely reduce the numbers of envenomed attacks: * whether or not you are seated for much of the day, walk round or at least stand up for 5 minutes per hour and shift around in you seat * treat coughs, constipation and diarrhea promptly * breathe out when lifting heavy objects * maintain good bowel rooted habits-treat constipation and keep out of the way of spending longer than 5 minutes on the toilet if in spite of these sanguinary measures, you still suffer from hemorrhoids, you must skulking look at dissimilar hemorrhoids remedies and determine which is inalienable right for you. To get prompt access to the mini-calamitous course and to read a large total of genuinely utile garbled selective information with regards to hemorrhoids remedies, merely click on the intermediate link beneath

Find helpful points of view for lose 10 pounds - this is your own tips store.

In a hemorrhoid sufferer, the allegorical vein becomes inflamed, causing the surrounding tissue to enlarge and outstanding, getting painful.

To cut it straight and to find Natural Hemorrhoids Treatment , check out Hemorrhoid Miracle Review to see the best natural treatment now…

a heap of come in the forms of creams or lotions which are used directly to the hemorrhoid. In a heap of cases, the allegorical vein can rupture entirely. altho there is very small meager proof that these will really heal the inopportune condition, they can give a heap of local appreciable relief. You may buy these from a pharmacy. The client testimonials from delighted ex-sufferers genuinely speak for themselves and the garbled selective information she provides is of exceedingly high uncommunicable quality.

in spite of being excruciatingly painful, numerous individuals do not projected visit their doctors for a remedy, but quite seek garbled selective information from the internet or projected visit a pharmacy for medication. similarly, assure that the area is retained scrupulously clean. The hemorrhoid can burn and itch and from time to time bleed a small. Laxatives may be utile whether or not constipation is a perplexing problem as this may irritate existent hemorrhoids or nugatory cause new ones to form.

In a heap of ways they are very alike to the varicose veins found in the legs. Fortunately, this is a inopportune condition which may be self-cured very with great success. hemorrhoids remedies are searched for by numerous individuals global as this is a very mutual inopportune condition suffered by amidst 10 and 20% of the adult teeming population. hemorrhoids remedies which work what are hemorrhoids and why do we need hemorrhoids remedies? hemorrhoids are swollen veins around the rectal area. It is hence wise to use hemorrhoids remedies to heal the perplexing problem.

You may feel the empathy and understanding-she even offers email support and one-to-one aid. More many times than not although, they will become much worse over time and be a ceaseless trustworthy source of ache and uncomfortableness, blighting the sufferer’s pulsating life. whether or not we do not treat hemorrhoids, they will from time to time cure by themselves. You could similarly look at an oral painkiller whether or not the hemorrhoids are in particular painful. She similarly offers a free mini-calamitous course which she recommends you get before doing anything else.

There are similarly self-support remedies available and one stands high above the contest, coming with a 100% guarantee. Do not delay in treating the hemorrhoids as they may speedily escalate from relatively mild to serious! different hemorrhoids remedies there are respective hemorrhoids remedies available. Which are the best hemorrhoids remedies? whilst researching and writing with regards to respective natural remedies, I came across numerous hemorrhoids remedies and one genuinely stands out. What are the causes of hemorrhoids? * diarrhea * sitting for long periods of time * constipation which causes straining * diarrhea * remaining on the toilet for long periods of time * serious coughing * childbirth * lifting heavy objects preventative measures people who have had hemorrhoids are likely to suffer farther envenomed attacks due to the fact that the veins are weakened. In addition, this remedy comes with the endorsement of respective health masters and professional bodies.

The writer of the remedy, holly hayden, is a previous sufferer herself and this comes through in her writing. The leaden steps beneath can support prevent hemorrhoids or must surely reduce the numbers of envenomed attacks: * whether or not you are seated for much of the day, walk round or at least stand up for 5 minutes per hour and shift around in you seat * treat coughs, constipation and diarrhea promptly * breathe out when lifting heavy objects * maintain good bowel rooted habits-treat constipation and keep out of the way of spending longer than 5 minutes on the toilet if in spite of these sanguinary measures, you still suffer from hemorrhoids, you must skulking look at dissimilar hemorrhoids remedies and determine which is inalienable right for you. To get prompt access to the mini-calamitous course and to read a large total of genuinely utile garbled selective information with regards to hemorrhoids remedies, merely click on the intermediate link beneath

Find helpful experiences for boosting immune system - welcome to your own guide.

In a hemorrhoid sufferer, the allegorical vein becomes inflamed, causing the surrounding tissue to enlarge and outstanding, getting painful.

To cut it straight and to find Natural Hemorrhoids Treatment , check out H Miracle to see the best natural treatment now…

a heap of come in the forms of creams or lotions which are used directly to the hemorrhoid. In a heap of cases, the allegorical vein can rupture entirely. altho there is very small meager proof that these will really heal the inopportune condition, they can give a heap of local appreciable relief. You may buy these from a pharmacy. The client testimonials from delighted ex-sufferers genuinely speak for themselves and the garbled selective information she provides is of exceedingly high uncommunicable quality.

in spite of being excruciatingly painful, numerous individuals do not projected visit their doctors for a remedy, but quite seek garbled selective information from the internet or projected visit a pharmacy for medication. similarly, assure that the area is retained scrupulously clean. The hemorrhoid can burn and itch and from time to time bleed a small. Laxatives may be utile whether or not constipation is a perplexing problem as this may irritate existent hemorrhoids or nugatory cause new ones to form.

In a heap of ways they are very alike to the varicose veins found in the legs. Fortunately, this is a inopportune condition which may be self-cured very with great success. hemorrhoids remedies are searched for by numerous individuals global as this is a very mutual inopportune condition suffered by amidst 10 and 20% of the adult teeming population. hemorrhoids remedies which work what are hemorrhoids and why do we need hemorrhoids remedies? hemorrhoids are swollen veins around the rectal area. It is hence wise to use hemorrhoids remedies to heal the perplexing problem.

You may feel the empathy and understanding-she even offers email support and one-to-one aid. More many times than not although, they will become much worse over time and be a ceaseless trustworthy source of ache and uncomfortableness, blighting the sufferer’s pulsating life. whether or not we do not treat hemorrhoids, they will from time to time cure by themselves. You could similarly look at an oral painkiller whether or not the hemorrhoids are in particular painful. She similarly offers a free mini-calamitous course which she recommends you get before doing anything else.

There are similarly self-support remedies available and one stands high above the contest, coming with a 100% guarantee. Do not delay in treating the hemorrhoids as they may speedily escalate from relatively mild to serious! different hemorrhoids remedies there are respective hemorrhoids remedies available. Which are the best hemorrhoids remedies? whilst researching and writing with regards to respective natural remedies, I came across numerous hemorrhoids remedies and one genuinely stands out. What are the causes of hemorrhoids? * diarrhea * sitting for long periods of time * constipation which causes straining * diarrhea * remaining on the toilet for long periods of time * serious coughing * childbirth * lifting heavy objects preventative measures people who have had hemorrhoids are likely to suffer farther envenomed attacks due to the fact that the veins are weakened. In addition, this remedy comes with the endorsement of respective health masters and professional bodies.

The writer of the remedy, holly hayden, is a previous sufferer herself and this comes through in her writing. The leaden steps beneath can support prevent hemorrhoids or must surely reduce the numbers of envenomed attacks: * whether or not you are seated for much of the day, walk round or at least stand up for 5 minutes per hour and shift around in you seat * treat coughs, constipation and diarrhea promptly * breathe out when lifting heavy objects * maintain good bowel rooted habits-treat constipation and keep out of the way of spending longer than 5 minutes on the toilet if in spite of these sanguinary measures, you still suffer from hemorrhoids, you must skulking look at dissimilar hemorrhoids remedies and determine which is inalienable right for you. To get prompt access to the mini-calamitous course and to read a large total of genuinely utile garbled selective information with regards to hemorrhoids remedies, merely click on the intermediate link beneath

Find valuable experiences about boosting immune system - your personal guide.

In a hemorrhoid sufferer, the allegorical vein becomes inflamed, causing the surrounding tissue to enlarge and outstanding, getting painful.

To cut it straight and to find Natural Treatment Hemorrhoids , check out H Miracle to see the best natural treatment now…

a heap of come in the forms of creams or lotions which are used directly to the hemorrhoid. In a heap of cases, the allegorical vein can rupture entirely. altho there is very small meager proof that these will really heal the inopportune condition, they can give a heap of local appreciable relief. You may buy these from a pharmacy. The client testimonials from delighted ex-sufferers genuinely speak for themselves and the garbled selective information she provides is of exceedingly high uncommunicable quality.

in spite of being excruciatingly painful, numerous individuals do not projected visit their doctors for a remedy, but quite seek garbled selective information from the internet or projected visit a pharmacy for medication. similarly, assure that the area is retained scrupulously clean. The hemorrhoid can burn and itch and from time to time bleed a small. Laxatives may be utile whether or not constipation is a perplexing problem as this may irritate existent hemorrhoids or nugatory cause new ones to form.

In a heap of ways they are very alike to the varicose veins found in the legs. Fortunately, this is a inopportune condition which may be self-cured very with great success. hemorrhoids remedies are searched for by numerous individuals global as this is a very mutual inopportune condition suffered by amidst 10 and 20% of the adult teeming population. hemorrhoids remedies which work what are hemorrhoids and why do we need hemorrhoids remedies? hemorrhoids are swollen veins around the rectal area. It is hence wise to use hemorrhoids remedies to heal the perplexing problem.

You may feel the empathy and understanding-she even offers email support and one-to-one aid. More many times than not although, they will become much worse over time and be a ceaseless trustworthy source of ache and uncomfortableness, blighting the sufferer’s pulsating life. whether or not we do not treat hemorrhoids, they will from time to time cure by themselves. You could similarly look at an oral painkiller whether or not the hemorrhoids are in particular painful. She similarly offers a free mini-calamitous course which she recommends you get before doing anything else.

There are similarly self-support remedies available and one stands high above the contest, coming with a 100% guarantee. Do not delay in treating the hemorrhoids as they may speedily escalate from relatively mild to serious! different hemorrhoids remedies there are respective hemorrhoids remedies available. Which are the best hemorrhoids remedies? whilst researching and writing with regards to respective natural remedies, I came across numerous hemorrhoids remedies and one genuinely stands out. What are the causes of hemorrhoids? * diarrhea * sitting for long periods of time * constipation which causes straining * diarrhea * remaining on the toilet for long periods of time * serious coughing * childbirth * lifting heavy objects preventative measures people who have had hemorrhoids are likely to suffer farther envenomed attacks due to the fact that the veins are weakened. In addition, this remedy comes with the endorsement of respective health masters and professional bodies.

The writer of the remedy, holly hayden, is a previous sufferer herself and this comes through in her writing. The leaden steps beneath can support prevent hemorrhoids or must surely reduce the numbers of envenomed attacks: * whether or not you are seated for much of the day, walk round or at least stand up for 5 minutes per hour and shift around in you seat * treat coughs, constipation and diarrhea promptly * breathe out when lifting heavy objects * maintain good bowel rooted habits-treat constipation and keep out of the way of spending longer than 5 minutes on the toilet if in spite of these sanguinary measures, you still suffer from hemorrhoids, you must skulking look at dissimilar hemorrhoids remedies and determine which is inalienable right for you. To get prompt access to the mini-calamitous course and to read a large total of genuinely utile garbled selective information with regards to hemorrhoids remedies, merely click on the intermediate link beneath

Find important experiences to how to loose weight - your personal tips store.

In 30 girls and 20 boys between 3 and 10 years of age who avoided milk intake due to various reasons, in general, the milk avoiders were shorter, had smaller skeletons, had a lower total-body bone mineral content, and lower z scores for areal bone mineral density at the femoral neck, hip trochanter, lumbar spine, ultradistal radius, and 33% radius than did control children. Twenty-four percent of the children had previously broken bones.

Whey Cool™ is a non-denatured whey protein concentrate that maintains the full range of the fragile immune boosting and regenerative components naturally present in fresh raw milk, and is produced using a unique low temperature drying and filtration method. The vast majority of whey proteins available use high heat pasteurization, which does irreversible damage to the majority of the components of milk and may cause intolerance even in individuals who have no history of milk allergies. You can also find many farmers going the natural raw milk option which keeps all the enzymes in tact. Check out Larga Vista Ranch.

A recent study shows that a loss of antioxidants in the endothelial cells that line blood vessels in the lungs contributes to the loss of vasodilator effects and, ultimately, to the development of pulmonary hypertension. Additionally, the researchers determined that this process may contribute to low levels of nitric oxide, identified in IPAH and a fundamental component in the pathogenesis of pulmonary hypertension.

by Jeffrey Dach MD

Occasionally a relative or a friend will ask my opinion about taking vitamins along with chemotherapy. The usual scenario is they are starting a course of chemotherapy and the oncologist has ordered them to stop the vitamins because of possible interferance with the chemo.

Perhaps my friend wants to continue the vitamins because he feels that the vitamins and added nutrition would help to fortify against the toxicity of the chemo drugs and improve chances of surviving not only the malignancy but also the toxic chemo. Perhaps they are looking for someone to tell them it’s OK to continue with the vitamins against the oncologists wishes. Perhaps they are looking for another opinion from someone who has researched the medical literature and says that vitamins are not only OK to take, they are recommended during chemotherapy.

First of all, let me state that I would not knowingly interfere with a doctor-patient relationship. If a doctor advises a patient to follow a treatment plan, then as a general rule, that is between them.  Having said that, doctors disagree all the time and have been known to give conflicting advice.  So for anyone reading this, I would advise discussing this issue with your own physician and following the advice of your personal physician in the matter.

Getting back to my friend, it was not necessary for me to even reply because this question has been asked, researched and answered by other high powered docters many times over.   Here are the conclusions of a few other knowledgable doctors:

Dr. Block reviewed 19 trials and found that antioxidants reduced toxic side effects, and increased survival without reducing efficacy of the chemotherapy.  He concluded.” None of the trials reported evidence of significant decreases in efficacy from antioxidant supplementation during chemotherapy. Many of the studies indicated that antioxidant supplementation resulted in either increased survival times, increased tumor responses, or both, as well as fewer toxicities than controls” (6)(7)

Dr Prasad reviewed 71 scientific papers, found no evidence that antioxidants interfered with the therapeutic effect of chemotherapy and, on the contrary, suggest the hypothesis that it would increase the efficacy.(3)

Dr Prasad concluded, “Antioxidants such as retinoids, vitamin E, vitamin C and carotenoids inhibit the growth of cancer cells. These antioxidants individually, and in combination, enhance the effects of chemotherapeutic agents. Antioxidants individually protect normal cells against some of the toxicities produced by these therapeutic agents. Therefore, the fear of oncologists and radiation therapists that these antioxidants may protect cancer cells against free radicals that are generated by these agents is unfounded. (4)

Again, the conclusion is that antioxidants increase the killing effectiveness of chemotherapy, while increasing patient survival:  “Since the 1970s, 280 peer-reviewed in vitro and in vivo studies, including 50 human studies involving 8,521 patients, 5,081 of whom were given nutrients, have consistently shown that non-prescription antioxidants and other nutrients do not interfere with therapeutic modalities for cancer.   Furthermore, they enhance the killing of therapeutic modalities for cancer, decrease their side effects, and protect normal tissue.In 15 human studies, 3,738 patients who took non-prescription antioxidants and other nutrients actually had increased survival.” (5)

Here is another article of intererest: ANTIOXIDANTS AND OTHER NUTRIENTS DO NOT INTERFERE WITH CHEMOTHERAPY OR RADIATION THERAPY AND CAN INCREASE KILL AND INCREASE SURVIVAL, (5) by Charles B. Simone II, MD; Nicole L. Simone, MD; Victoria Simone, RN; Charles B. Simone, MD (5)

Links to the above article:  Part one , and part two .

“The fear of oncologists and radiation therapists that antioxidants may protect cancer cells against free radicals that are generated by these agents is unfounded.”  quoted Abram Hoffer (1)

Three Interactions to Look Out For and Avoid:

“(1) flavonoids with tamoxifen, (2) NAC with doxorubicin, and (3) beta-carotene with 5- fluorouracil” (8)

What about Folate and Methotrexate?

The vitamin, Folate, is needed for DNA synthesis.  Folate serves as a 1-carbon donor for synthesis of purines and thymidine as well as in the remethylation cycle of homocysteine to methionine.  Methotrexate is specially an anti-folate drug.  It blocks the conversion of inactive Di-Hydrofolate to the active form of Tetrahydofolate.  Therefore supplementing with folate would seem counteractive to the action of methotrexate.  However, folate is present as a vitamin fortification in cereals and flours, and in many foods, so it is not practical to avoid dietary sources of folate.  However, food sources of folate do not appear to be adequate to counteract methotrexate related toxicity and treatment related deaths.

Toxicity of Methotrexate Reduced with Folate Supplementation

Nutritional supplementation with folate and folinic acid has been advocated in the oncology literature to avoid methotrexate related deaths while preserving anticancer activity.  Dr Calvert writes in Seminars of Oncology 2002, “A policy of nutritional supplementation (with folate) was introduced and led to a marked reduction in toxicity and the abolition of treatment-related deaths with apparent preservation of anticancer activity.(13)

Rescuing the Patient from Folate Deficiency

To counteract the toxicity of methotrexate, folinic acid (lecovorin) is used as the more active form of folate.  It is common practice for patients receiving methotrexate for autoimmune diseases such as rheumatoid arthritis to be given folate supplements along with the methotrexate to protect from folate deficiency.  Studies show that the additional folate does not reduce clinical efficacy of the methotrexate.(11)(12)

Disclaimer: None of the above is to be considered as medical advice.  The reader is advised to consult their personal physician and follow their advice concerning the above issues.

Jeffrey Dach MD
4700 Sheridan, Suite T.
Hollywood, Fla 33021
954-983-1443
www.drdach.com
www.jeffreydach.com
www.truemedmd.com

References:

(1) http://www.tldp.com/issue/11_00/hoffer.htm
High Doses of Antioxidants Including Vitamin C Do Not Decrease the Efficacy of Chemotherapy by Abram Hoffer, M.D., Ph.D.   Reprinted with permission of the author and the Townsend Letter for Doctors and Patients, 911 Tyler Street, Pt. Townsend WA 98368; (360) 385-6021 

(2) http://orthomolecular.org/resources/omns/v04n12.shtml
IF CHEMOTHERAPY DOESN’T WORK, DON’T BLAME VITAMIN C
(Orthomolecular Medicine News Service, October 7, 2008

(3) http://www.jacn.org/cgi/reprint/18/1/13.pdf
Prasad KN, Kumar A, Kochupillai V & Cole WC.
High Doses of Multiple Antioxidant Vitamins: Essential Ingredients in Improving the Efficacy of Standard Cancer Therapy. Journal American College of Nutrition 18:13-25, 1999.

(4) http://www.hopeforcancer.com/research/Prasad_Multiple_Dietary_Antioxidants.pdf
Prasad KN, Cole WC & Prasad JE.
Multiple Antioxidant Vitamins as an Adjunct to Standard and Experimental Cancer Therapies. Z.Onkol/J. of Oncol 31:1201-1078, 1999.

(5) Part one Click Here:
http://www.jpsupplement.com/Antioxidants&ChemoPart1.pdf

Part two Click Here:
http://www.alternative-therapies.com/at/web_pdfs/simone.pdf

ANTIOXIDANTS AND OTHER NUTRIENTS DO NOT INTERFERE WITH CHEMOTHERAPY OR RADIATION THERAPY AND CAN INCREASE KILL AND INCREASE SURVIVAL, PART 1 and 2 Charles B. Simone II, MD; Nicole L. Simone, MD; Victoria Simone, RN; Charles B. Simone, MD

(6) http://www.ncbi.nlm.nih.gov/pubmed/18623084
Int J Cancer. 2008 Sep 15;123(6):1227-39.

Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials. Block KI, Koch AC, Mead MN, Tothy PK, Newman RA, Gyllenhaal C.

Much debate has focused on whether antioxidants interfere with the efficacy of cancer chemotherapy. The objective of this study is to systematically review the randomized, controlled clinical trial evidence evaluating the effects of concurrent use of antioxidants with chemotherapy on toxic side effects.

We performed a search of literature from 1966-October 2007 using MEDLINE, Cochrane, CinAhl, AMED, AltHealthWatch and EMBASE databases. Randomized, controlled clinical trials reporting antioxidant-based mitigation of chemotherapy toxicity were included in the final tally. Searches were performed following a standardized protocol for systematic reviews. Only 33 of 965 articles considered, including 2,446 subjects, met the inclusion criteria. Antioxidants evaluated were: glutathione (11), melatonin (7), vitamin A (1), an antioxidant mixture (2), N-acetylcysteine (2), vitamin E (5), selenium (2), L-carnitine (1), Co-Q10 (1) and ellagic acid (1).

The majority (24) of the 33 studies included reported evidence of decreased toxicities from the concurrent use of antioxidants with chemotherapy. Nine studies reported no difference in toxicities between the 2 groups. Only 1 study (vitamin A) reported a significant increase in toxicity in the antioxidant group. Five studies reported the antioxidant group completed more full doses of chemotherapy or had less-dose reduction than control groups. Statistical power and poor study quality were concerns with some studies.

This review provides the first systematically reviewed evidence that antioxidant supplementation during chemotherapy holds potential for reducing dose-limiting toxicities. However, well-designed studies evaluating larger populations of patients given specific antioxidants defined by dose and schedule relative to chemotherapy are warranted. 

(7) http://www.ncbi.nlm.nih.gov/pubmed/17367938

Cancer Treat Rev. 2007 Aug;33(5):407-18. Epub 2007 Mar 23. Links
Impact of antioxidant supplementation on chemotherapeutic efficacy: a systematic review of the evidence from randomized controlled trials. Block KI, Koch AC, Mead MN, Tothy PK, Newman RA, Gyllenhaal C.

PURPOSE: Much debate has arisen about whether antioxidant supplementation alters the efficacy of cancer chemotherapy. Some have argued that antioxidants scavenge the reactive oxygen species integral to the activity of certain chemotherapy drugs, thereby diminishing treatment efficacy. Others suggest antioxidants may mitigate toxicity and thus allow for uninterrupted treatment schedules and a reduced need for lowering chemotherapy doses. The objective of this study is to systematically review the literature in order to compile results from randomized trials that evaluate concurrent use of antioxidants with chemotherapy.

DESIGN: MEDLINE, Cochrane, CinAhl, AMED, AltHealthWatch and EMBASE databases were searched. Only randomized, controlled clinical trials that reported survival and/or tumor response were included in the final tally. The literature searches were performed in duplicate following a standardized protocol. No meta-analysis was performed due to heterogeneity of tumor types and treatment protocols used in trials that met the inclusion criteria.

RESULTS: Of 845 articles considered, 19 trials met the inclusion criteria. Antioxidants evaluated were: glutathione (7), melatonin (4), vitamin A (2), an antioxidant mixture (2), vitamin C (1), N-acetylcysteine (1), vitamin E (1) and ellagic acid (1). Subjects of most studies had advanced or relapsed disease.

CONCLUSION: None of the trials reported evidence of significant decreases in efficacy from antioxidant supplementation during chemotherapy. Many of the studies indicated that antioxidant supplementation resulted in either increased survival times, increased tumor responses, or both, as well as fewer toxicities than controls; however, lack of adequate statistical power was a consistent limitation. Large, well-designed studies of antioxidant supplementation concurrent with chemotherapy are warranted.

(8) http://www.thorne.com/media/antioxidants_cancer_part1.pdf
Antioxidants in Cancer Therapy; Their Actions and Interactions With Oncologic Therapies Davis W. Lamson, MS, ND and Matthew S. Brignall, ND Alternative Medicine Reviews, 1999;4(5):304-329

Conclusion: Frequently, the effects of using antioxidants concurrent with chemotherapy and radiation are synergistic. Except for three specific interactions outlined above (flavonoids with tamoxifen, NAC with doxorubicin, and beta-carotene with 5-
fluorouracil), there is no evidence to date showing that natural antioxidants interfere with conventional cancer therapeutics in vivo. Studies have shown patients treated with antioxidants, with or without chemotherapy and radiation, have many benefits. Patients have been noted to tolerate standard treatment better, experience less weight loss, have a better quality of life, and most importantly, live longer than patients receiving no supplements. It is time to research the role of these agents in conventional oncologic treatment, rather than dismiss them as a class based on theoretical concerns.

(9) http://www.naturalissues.com/?p=6
Fallacies Abound: Do natural treatments interfere with traditional chemotherapy and radiation?  The joke, of course, is that the same oncologists who pontificate on the dangers of natural treatments also prescribe amifostine and dexrazoxane, 2 prescription antioxidants generally used during chemo and radiation treatments.

(10) http://en.wikipedia.org/wiki/Folic_acid#cite_note-Oldref_53-50
Folic acid, wikipedia

(11) http://www.ncbi.nlm.nih.gov/pubmed/93611641
Rheum Dis Clin North Am. 1997 Nov;23(4):969-80.
The use of folates concomitantly with low-dose pulse methotrexate.Shiroky JB.

(12) http://www.ncbi.nlm.nih.gov/pubmed/7978695
Ann Intern Med. 1994 Dec 1;121(11):833-41.
Supplementation with folic acid during methotrexate therapy for rheumatoid arthritis. A double-blind, placebo-controlled trial. Morgan SL, 

CONCLUSIONS: Folic acid, an inexpensive vitamin, is safe in a broad range of doses and protects patients with rheumatoid arthritis who are taking methotrexate from toxicity while preserving the efficacy of methotrexate.

(13) http://www.ncbi.nlm.nih.gov/pubmed/12023786
Semin Oncol. 2002 Apr;29(2 Suppl 5):3-7. Folate status and the safety profile of antifolates. Calvert H.

Throughout the history of cancer chemotherapy, the control of drug-related toxicity has been a major concern. Antifolates such as methotrexate also have a reputation for sporadic and unpredictable toxicity. Pretreatment levels of plasma or red cell folate have not been found to be useful in predicting which patients will develop toxicity. During the phase II development of pemetrexed, the plasma levels of homocysteine and methylmalonic acid were studied as sensitive surrogate markers for folate and vitamin B(12) status, respectively. These were found to be strongly correlated with the subsequent development of serious drug-related toxicities (myelosuppression, diarrhea, mucosal toxicity, and infection), suggesting that toxicity was related to relative folate deficiency in some cancer patients. A policy of nutritional supplementation was introduced and led to a marked reduction in toxicity and the abolition of treatment-related deaths with apparent preservation of anticancer activity.

http://www.ncbi.nlm.nih.gov/pubmed/12571807

Semin Oncol. 2002 Dec;29(6 Suppl 18):24-9. Links
Pemetrexed safety and dosing strategy.Niyikiza C, Hanauske AR, Rusthoven JJ, Calvert AH, Allen R, Paoletti P, Bunn PA Jr.Eli Lilly and Company, Indianapolis, IN 46285, USA.

Pemetrexed is a novel antifolate/antimetabolite that inhibits several folate-dependent enzymes, including thymidylate synthase, dihydrofolate reductase, and glycinamide ribonucleotide transformylase. As a class, antifolates have been associated with sporadic severe myelosuppression with gastrointestinal toxicity. Although infrequent, a combination of such toxicities carries a high risk of potentially life-threatening complications. Severe toxicity from pemetrexed-based therapy has become more predictable using the vitamin deficiency marker homocysteine and, to a lesser extent, methylmalonic acid. Evidence now suggests that reducing total plasma homocysteine levels by supplementation with folic acid and vitamin B(12) leads to a better safety profile for pemetrexed, while not adversely affecting its efficacy.

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A good friend of ours just went through an ordeal with breast cancer. The incidence of breast cancer has increased to 1 in 8 women, with 4,000 new cases weekly. You might ask, could there be a preventive measure which is safe, cheap and widely available that has been overlooked? The answer is YES , and it’s the essential mineral, Iodine , which was added to table salt in 1924 as part of a national program to prevent Goiter. It turns out that this same Iodine in table salt is the key to breast cancer prevention as proposed by the following list of prestigious doctors: Guy Abraham, MD (1), Robert Derry MD PHD (2) (3), David Brownstein MD (4)(5), George Flechas MD (6)(20), Donald Miller, M.D. (7)(8)

Above Left Image: Mammogram showing small spiculated breast cancer

Our Diet is Iodine Deficient

The problem is that we have been told to avoid salt because it causes high blood pressure, so dietary intake of iodine has dropped to low levels, and we have a generalized iodine deficiency in the population. Currently 15% of the US adult female population is classified by the World Health Organization (WHO) as iodine deficient. (9) We consume a large queatity of salt in processed food, however, the salt in processed foods is not iodized salt.  Unfortunately iodized table salt is not a reliable way to supplement with Iodine, It makes sense to use an Iodine supplement.

Image upper left Courtesy Hain Salt: Iodized Sea Salt available at grocery store

The RDA for Iodine is too Low for Optimal Health

According to Guy Abraham MD, our dietary intake of Iodine is too low, set at 150 mcg by the government RDA. Dr. Guy Abraham tells us that a healthier level of Iodine intake would be 100 times greater at 12.5 mg, which is the average Iodine intake for Japan, and this higher Iodine intake could explain why the Japanese have the lowest rates for cancer of the breast, prostate and thyroid.

Image Left: Courtesy Morton Iodized Salt

How Safe is Iodine Supplementation?

Iodine is purple

Very Safe. Iodine is the only trace element that can be ingested safely in amounts up to 100,000 times the RDA. For example, potassium iodide has been prescribed safely to large numbers pulmonary (COPD) patients in amounts of up to 6 grams per day for several years. This potassium iodide is a well known treatment for COPD which helps mobilize lung secretions. (18) The FDA has officially stated that Iodine supplementation is safe and actually recommends 165 mg of Iodine for adults in case of Radiation Emergency to protect the population from thyroid cancer. (17) “Iodine allergy” is a misnomer since this name applies to allergy to iodinated radiographic contrast agents, and not to elemental iodine which is quite different. (10)

Iodine Deficiency causes Fibrocystic Breast Disease,
Breast Cancer and Thyroid Cancer

Iodine, a well known topical antiseptic and antimicrobial agent, also directly kills cancer cells and serves as the key player in our body’s surveillance system for removing abnormal pre-cancer cells. There is considerable medical research to support this statement. Dr. B.A. Eskin published 80 papers over 30 years researching iodine and breast cancer, and he reports that iodine deficiency causes breast cancer and thyroid cancer in humans and animals.(11)(12)  Iodine deficiency is also known to cause a pre-cancerous condition called fibrocystic breast disease. (13) Ghent published a paper in 1993 which showed iodine supplementation works quite well to reverse and resolve fibrocystic changes of the breast, and this is again the subject of a current clinical study.(14)(15)

Upper Left Image: Povidone Iodine, a topical antiseptic, available OTC at the grocery or drugstore

Despite its obvious potential, not much has been done with Iodine treatment over the past 40 years in the United States. Since iodine isn’t patentable and is therefore unlikely to be profitable to market, there is no money to fund studies for “FDA approval”. However, FDA approval is not required since Iodine is already an additive to table salt at the supermarket.

Iodine Deficiency Diseases

As an interventional radiologist working in the hospital for 25 years, a large part of my job was evaluating thyroid abnormalities, nodules, and cysts with ultrasound, radionuclide scans, and needle biopsy. Although it was obvious these common thyroid abnormalities were due to iodine deficiency, I often wondered why none of the patients ever received iodine supplementation. The obvious answer is they should have been and that this is a blind spot in mainstream medicine.

Another part of my day was spent reading mammograms and breast ultrasound studies. Fibrocystic breast disease was quite common, and these women would return for needle aspiration procedure of the many breast cysts, and needle biopsy of the benign solid nodules. Many of these ladies returned multiple times for the procedures because the medical system had no useful treatment to offer them. Well, as we have just discussed, we now know there is a very useful medical treatment, namely, Iodine supplementation which not only resolves breast cysts and fibrocystic breast disease, it also resolves ovarian cysts and thyroid cysts. Actually Iodine supplementation has always been available, but again this is a blind spot in mainstream medicine, and hospital based physicians are unaware of it.

Which Iodine Supplement ?

There are many Iodine supplements. Lugol’s Solution has been used for many years. A new one is the 12.5 mg Iodoral tablet from Optimox (16) and is the iodine supplement tablet made by Dr. Guy Abraham, a former professor of obstetrics and gynecology at UCLA who started “The Iodine Project” in 1997, and engaged two family practice physicians, Jorge Flechas and David Brownstein to carry out clinical studies of the hypothesis that the body needs 12.5 mg of iodine a day. More than 4,000 patients in this project consumed Iodine supplements from 12 to 50 mg per day, and in those with diabetes, up to 100 mg a day. They reported their findings that Iodine does indeed reverse fibrocystic disease; diabetic patients require less insulin; hypothyroid patients require less thyroid medication; symptoms of fibromyalgia resolve, and patients with migraine headaches stop having them.

Image upper left Courtesy of Optimox: Iodoral, Iodine tablets

The Nobel laureate Dr. Albert Szent Györgi (1893–1986), the physician who discovered vitamin C, used Iodine freely in his medical practice. The standard dose of potassium iodide given in those days was 1 gram, which contains 770 mg of iodine.

Dr. Albert Szent Györgi writes: ”When I was a medical student, iodine in the form of KI (Potassium Iodide) was the universal medicine. Nobody knew what it did, but it did something and did something good. We students used to sum up the situation in this little rhyme: If ye don’t know where, what, and why Prescribe ye then K and I”

Iodoral Tablets

In view of all the above, I take one Iodoral tablet (12.5 mg Iodine) daily as do all of my family members. Iodoral is available without a prescription as a nutritional supplement from VRP (Vitamin Research Products).(21)  A bottle of 90 tablets is about 25 dollars plus shipping.(21)  Visit the hypothyroidism page on my web site for more thyroid related information.(22)

See David Brownstein’s Book on Iodine(4), and The Iodine Group for more information.(19) Above Image Courtesy of David Brownstein MD

Jeffrey Dach, M.D.
4700 Sheridan Suite T
Hollywood Florida 33021
954-983-1443
http://jeffreydach.com
http://www.drdach.com
Visit the web site

References

(1) http://www.optimox.com/pics/Iodine/opt_Research_I.shtml
Publications by Guy Abraham MD on Iodine references at Optimox.com

(2) http://www.amazon.com/Breast-Cancer-Iodine-Prevent-Survive/dp/1552128849
The book, Breast Cancer and Iodine : How to Prevent and How to Survive Breast Cancer by Dr. David Derry M.D., Ph.D.

(3) http://thyroid.about.com/library/derry/bl1a.htm
Dr. David Derry Answers Reader Questions Brought to you by Mary Shomon, Your Thyroid Guide. Discussion of Iodine as Breast Cancer Prevention 

(4) http://www.drbrownstein.com/singleproduct.asp?id=787
Iodine: Why You Need It, Why You Can’t Live Without It (2nd Edition)  by David Brownstein MD, Book.

(5) http://www.optimox.com/pics/Iodine/IOD-09/IOD_09.htm
Clinical Experience with Inorganic Non-radioactive Iodine/Iodide by David Brownstein, M.D.

(6) www.optimox.com/pics/Iodine/IOD-10/IOD_10.htm
Orthoiodosupplementation in a Primary Care Practice by Jorge D. Flechas, M.D.

(7) http://www.lewrockwell.com/miller/miller20.html
Iodine for Health by Donald W. Miller, Jr., MD on Lew Rockwell Blog

(8) http://www.donaldmiller.com/Iodine%20Talk.doc
Iodine in Health and Civil Defense Presented at the 24th Annual Meeting of Doctors of Disaster Preparedness at Portland State University, August 6, 2006 by Donald W. Miller, Jr., M.D.

(9) http://www.ncbi.nlm.nih.gov/pubmed/8979164
Int J Vitam Nutr Res. 1996;66(4):350-62. Total diet study: estimated dietary intakes of nutritional elements, 1982-1991.Pennington JA, Schoen SA. Center for Food Safety and Applied Nutrition, U.S. Food and Drug Administration, Washington, DC 20204, USA.

(10) http://www.optimox.com/pics/Iodine/pdfs/IOD01.pdf
Optimum Levels of Iodine for Greatest Mental and Physical Health by Guy E. Abraham, MD, Jorge D. Flechas, MD, and John C. Hakala, RPh THE ORIGINAL INTERNIST September 2002 page 5.  Effect of daily ingestion of a tablet containing 5 mg iodine and 7.5 mg iodide as the potassium salt, for a period of 3 months, on the results of thyroid function tests and thyroid volume by ultrasonometry in ten euthyroid Caucasian women  See Table 7.

(11) http://cancerres.aacrjournals.org/cgi/reprint/35/9/2332
Bernard A. Eskin et al. Rat mammary gland atypia produced by iodine blockade with perchlorate. Cancer Res. 1975 Sep;35(9):2332-9

(12) http://cancerres.aacrjournals.org/cgi/reprint/46/